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Dowling-Degos disease

4 OMIM references -
3 associated genes
No signs/symptoms info

PROTEIN INTERACTIONS: 1

Ichthyosis hystrix of Curth-Macklin

1 OMIM reference -
1 associated gene
8 signs/symptoms

Dowling-Degos disease

Ichthyosis hystrix of Curth-Macklin

KRT5	(UniProt - OMIM)		KRT1	(UniProt - OMIM)
POFUT1	(UniProt - OMIM)
POGLUT1	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	KRT5	(0.52)	KRT1

Citations in the biomedical literature:

Dowling-Degos disease		Ichthyosis hystrix of Curth-Macklin
	Synonym(s): - Reticular pigment anomaly of flexures		Synonym(s): - Ichthyosis hystrix, Curth-Macklin type

	Classification (Orphanet): - Inborn errors of metabolism - Rare genetic disease - Rare skin disease		Classification (Orphanet): - Rare genetic disease - Rare skin disease

	Classification (ICD10): - Diseases of the skin and subcutaneous tissue -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: adolescence / young Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: normal Type of inheritance: autosomal dominant

	External references: 4 OMIM references - No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: C536088

Ichthyosis hystrix of Curth-Macklin
	Very frequent - Autosomal dominant inheritance - Chronic skin infection / ulcerations / ulcers / cancrum - Follicular / erythematous / edematous papules / milium - Hyperkeratosis / ainhum / hyperkeratotic skin fissures - Ichthyosis / ichthyosiform dermatitis Frequent - Abnormal fingernails - Contractures / cramps / trismus / tetania / claudication / opisthotonos Occasional - Gangrena / necrosis
Dowling-Degos disease
(no data available)